Mode of action determined by the properties included in the components of the drug. Heparin prevents the formation of blood clots, prevent blood coagulation in hemorrhoids, has anti-edematous effect, promotes regeneration unite tive tissue, accelerates healing and reduces the number of relapses. Heparin inhibits reactions that cause the blood coagulate and form a fibrin clot. Heparin is given at a dosage in combination with antithrombin III plasma inhibits thrombosis by deactivating factor Xa and inhibition of the conversion of prothrombin to thrombin. Heparin prevents the formation of a stable fibrin clot by inhibiting the activation of the fibrin-stabilizing factor. Heparin also exhibits anti-inflammatory effects, affecting the vascular endothelium prevents edema.
Prednisone belongs to a group masteron enanthate of synthetic glucocorticoids average duration, reduces the formation, release and activity of mediator of inflammation (histamine, kinin, prostaglandin, lysosomal enzymes). Suppresses cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in inflammation. Decreases exudation due to vasoconstriction. Inhibits the action of macrophages, the target cells, cytokines, which are involved in the development of allergic reactions. It prevents access 1 sensitized lymphocytes and macrophages to target cells. It has anti-inflammatory, and anti-allergic effect protivoekssudativnoe, reduces inflammation and associated subjective sensations (itching, burning, pain, feeling of humidity due to eczematous changes) in the anorectal region.
Lidocaine has a local anesthetic effect, which is caused by the blockade of sodium channels voltazhzavisimyh that prevents the generation of impulses in sensory nerve endings and conduct pain impulses along nerve fibers. The combined action of the components of the drug achieved the best effect.
Heparin and prednisolone effectively absorbed following rectal administration, penetrate the intestinal wall for several hours, and then gradually be transported via the portal circulation to the liver, where biotransformed oxidizing enzyme into metabolites and excreted through the kidneys. The half-life of heparin is 1 – 1.5 hours, prednisolone -18-36 hours.
For rectal application of the lidocaine (35%) is exposed to systemic absorption. The maximum blood concentration of lidocaine reached after 2 h. Lidocaine is rapidly metabolised in the liver and masteron enanthate excreted through the kidneys. Part of lidocaine undergoes enterohepatic circulation and is excreted in the feces. The half-life is from 1 to 3 hours.
Indications for use:
External and internal hemorrhoids, including acute thrombophlebitis of hemorrhoidal veins of the perianal region, fistulas, eczema, itching in the anus, caused by inflammation, anal fissures, preparation for surgery in the anorectal area in the complex therapy of thrombosed hemorrhoids and operated.
Hypersensitivity to the drug.
Viral, fungal, tuberculosis and other infectious masteron enanthate processes anorectal disorders of the coagulation system with a predisposition to bleeding. Pregnancy and lactation. Children under 12 years old.
Dosing and Administration:
When an internal hemorrhoid suppository inserted into the cavity of the rectum 1-2 times per day. For external hemorrhoids suppository administered anus incompletely – its base should be palpable outside.Hold the anus gauze until complete melting of the suppository (2-3 minutes), or suppository “fail” in the rectum, without putting therapeutic action. The course of treatment – 7 days. According to the doctor’s recommendation course can be extended to 14 days.
The drug is generally well tolerated. At the recommended dose of the drug adverse effects were detected.
Using the drug for more than 5 weeks are possible systemic masteron enanthate side effects associated with the effect of prednisolone:
From endocrine system: reduction of glucose tolerance, “steroid” diabetes, adrenal suppression, Cushing’s syndrome. On the part of the cardiovascular system are possible arrhythmia, bradycardia (in predisposed patients), ECG changes typical of hypokalemia, increased blood pressure.
From the nervous system: insomnia, dizziness.
On the part of metabolism: increased excretion of calcium ions, hypocalcemia, increased sweating.
Allergic reactions caused by lidocaine and heparin in the form of itching and irritation of the anus.
Rectal suppositories. 5 pieces in blisters made of PVC film. Two contour package together with instructions for use in paper cartons.
In dry the dark place at a temperature no higher than 25 ° C. Keep out of the reach of children.